It is 1693 in Hereford, Connecticut, when Mary Case, the spinster daughter of a Puritan minister, finds herself hopelessly smitten by roguish thief Daniel Eames. Betrothed to a man she does not like or love, she is soon compelled to help Daniel escape from jail. Suddenly she finds herself on the run, not only accused of being Daniel's accomplice but also of murder.

The fugitive pair soon finds solace - and a mutual attraction - among the escapee's Algonquin friends until two men from Daniel's dark past hunt them down. After Mary is captured and returned home to await trial, a tragedy takes the life of her younger sister, revealing a dark secret Mary's father has kept for months. But just as Mary learns she is pregnant, she makes a horrifying discovery about Daniel that changes everything and prompts her to develop an unlikely bond with his mother, Rebecca, who soon saves Mary from a shocking fate. It is not until years later that her daughter, Kezia, finally learns the truth about her biological father and family.

Letters to Kezia shares a courageous woman's journey through a Puritan life and beyond as she struggles with adversity and betrayal and discovers that loyalty can sometimes mean the difference between life and death.