Let's Know Things Podcast Por Colin Wright capa

Let's Know Things

Let's Know Things

De: Colin Wright
Ouça grátis

A calm, non-shouty, non-polemical, weekly news analysis podcast for folks of all stripes and leanings who want to know more about what's happening in the world around them. Hosted by analytic journalist Colin Wright since 2016.

letsknowthings.substack.comColin Wright Política e Governo
Episódios
  • English Hepatitis C Progress

    English Hepatitis C Progress
    Aug 18 2026
    This week we talk about the liver, viral infections, and the NHS.We also discuss blood scandals, needle usage, and Nobel Prizes.Recommended Book: A World Appears by Michael PollanTranscriptThe term “hepatitis” refers to the inflammation of the liver, which can result from all kinds of things, including environmental toxins, the consumption of alcohol, or autoimmune diseases. It can also result from viral infections, and the most prominent liver-inflaming viruses are called viral hepatitis.There are five types of viral hepatitis, A, B, C, D, and E, and each of these viruses are distinct, not part of the same viral family, they’re just similarly named because they impact the same organ.Hepatitis A and E are primarily spread through contaminated food and water, and generally resolve on their own, untreated, and cause relatively mild symptoms. Hepatitis B and C are spread through blood and other bodily fluids, and can linger in a host’s body for decades before even showing symptoms. Hepatitis D is a parasite of Hepatitis B, and thus only infects people who carry Hepatitis B.Now again, these are all different conditions that just happen to inflame the liver, so impact and treatment also vary quite a lot. As I mentioned, A and E generally present with mild symptoms and tend to go away on their own, while B and C can stick around a long time. There’s a vaccine for B, but no cure; you can treat it, but that treatment involves suppressing it, and keeping it suppressed, forever. Hep C, in contrast, is curable, and has been since 2014 using what are called direct-acting antiviral pills, but these pills, which are taken for 8 to 12 weeks, are expensive—ranging from $22-95k without insurance, though that price is often reduced substantially for those with insurance, down to as low as $5. This category of drug coverage is often rejected by insurance companies, though, in part because they’re so expensive, that expense the result of little competition in this space; few companies make this type of drug, so those that do can charge more or less whatever they like.Some people with Hepatitis C clear it on their own; about 30% of people who contract it, in fact, clear it within a few months, medication-free. Which is good, because our understanding of this virus is relatively new. Up until 1989, Hep C didn’t even have its own name: it was established as its own thing, not Hep A and not Hep B, back in the 1970s, and doctors knew that something that wasn’t those two viruses, that was being spread by transfusions, was causing hepatitis symptoms, but they didn’t know any real specifics, so they just called it “non-A, non-B hepatitis,” and that name stuck for more than a decade.In 1989 the virus was cloned using molecular techniques (as opposed to simply growing the virus, which wasn’t proving fruitful in trying to isolate and identify the thing), and the folks who managed that cloning, and the person who later proved that the genome they cloned, alone, caused the disease, received a Nobel Prize in Medicine for their efforts in 2020.By 1991, antibody tests were available for Hep C, and many countries began screening donated blood for this virus, to ensure it wasn’t working its way into their blood supply.And one instance of that screening process, or I suppose, an event that led up to mass screening, and the consequences that followed, are what I’d like to talk about today. The UK’s efforts in trying to eliminate Hep C, and England’s recently announced near-success in that pursuit.—Hepatitis C is an RNA virus with high genetic variability that makes developing a reliable vaccine difficult. And though somewhere between a quarter and a third of all cases clear on their own, those that don’t clear on their own become chronic, lying in wait for twenty to thirty years, slowly accumulating fibrosis—thick scar tissue in the liver—which eventually results in cirrhosis, which means a liver that’s so heavily scarred that the organ is no longer fully functional and the damage is permanent. From there, infected people often experience liver failure or hepatocellular (huh-pah-toe) carcinoma, liver cancer.So this virus is a sleeper, and unless it’s caught by accident somewhere along the way, it slowly causes damage over time until the damage is too severe to reverse. About 80% of people who have it don’t know they have it, and in some parts of the world medical injections are the most common transmitter, but in higher-income areas, it’s usually transmitted by injectable drugs.Pre-2014 treatments for Hep C were pretty horrible, involving a combination antiviral therapy called pegylated interferon plus ribavirin that was injected weekly for six months to a year, and this was terribly tolerated by pretty much everyone, causing anemia, depression, and flu-like symptoms for the duration. It also only cured about 50% of people who received the full treatment, and a lot of people had to stop ...
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    16 minutos
  • AI-Designed Viruses

    AI-Designed Viruses
    Aug 11 2026
    This week we talk about Evo 2, bacteriophages, and antibiotics.We also discuss AI models, medical innovations, and the Red Army.Recommended Book: The Design of Everyday Things by Donald A. NormanTranscriptA bacteriophage, sometimes just called a phage, is a type of virus that only infects bacteria. “Phage” means to devour, and that’s what bacteriophages do—they infect and replicate within bacteria that they target, injecting their own genome into that target’s cytoplasm, which are all the materials contained within the bacteria’s cell membrane.Phages are super-abundant, by some measures more abundant than every living organism, including bacteria, on earth, combined. And they’re interesting in that they range from incredibly simple to quite complex, and have at times been used as alternatives to antibiotics, because they attack and feed on bacteria.The use of phages to counter bacterial infections was all but abandoned in the mid-20th century when antibiotics were discovered and commercialized, their production industrialized and the substances themselves proving a lot easier to mass-produce, and a lot more predictable in their utility than phages. Phages were kinda sorta almost understood, but we didn’t really get what they were doing or why, so their application often felt more like folk remedies than real-deal science, despite the actual science underlying the practice.Also, phages were primarily used as antibiotic treatments by the Red Army, the Soviet Union’s military. So throughout the West, which was rapidly scaling its production of antibiotic treatments, the use of bacteriophages was associated with Stalinist communism, and so the Red-scare, the demonization of anything associated with the Soviet Union, was partially responsible for the shelving of this approach and this realm of research, at least for a while.Much of that existing research was also done in the Soviet Union, and the published documents were thus published in Russian or Georgian languages. And because much of the rest of the scientific publishing world was reorienting around English at this time, that meant these published works were often either ignored or unintelligible to the rest of the scientific community.As with much of our microbiota, the invisibly small viruses, bacteria, archaea, and so on that make up the human microbiome, we have a general sense of how bacteriophages interact with some of what makes us, us, but only a general sense. We know that healthy individuals tend to contain a host of bacteriophages that people who have chronic conditions, like Crohn’s disease or ulcerative colitis are less likely to have, for instance, and there’s a chance that this lack is associated with those conditions—though each person’s body composition is unique, and this facet of biology is still relatively obscure; we really don’t know for certain what does what, because of how complex these interactions are.What I’d like to talk about today is a recent development in the world of bacteriophages, and why the researchers behind it are both celebrating their accomplishment, and warning about potential dangers associated with the same.—Back in 2025, a nonprofit called the Arc Institute, which has a stated goal of accelerating scientific progress and understanding the root causes of complex diseases, announced the release of a new language model, a new AI system, called Evo 2.The Evo family of foundation models—a foundation model being a type of AI model that’s been trained on a huge corpus of data, but which is applicable for all sorts of purposes, including serving as the foundation of large-language models like ChatGPT or Claude—this family of foundation models is open-source and trained on raw genetic sequences, something like nine trillion nucleotides-worth of such sequences, making it distinct from other models in this space that have been trained on descriptions of biological systems, using human language.The initial version of Evo was released in early 2024, and the newest version, Evo 2, which is an upgraded version of the Evo 2 model that is more efficient, so it can be run on less powerful hardware, was released in February of 2026.So while many of the AI systems that non-biologists interact with on a regular basis have been trained on human language-based libraries, showing relationships and interactions between the words we use to communicate, these models have been trained on the fundamental building blocks of life; the nucleotides, Adenine, Thymine, Cytosine, and Guanine, ATCG of DNA, if you remember that from biology class, that are strung together into 64 different possible three-letter combinations. Chains of these nucleotides instruct cells to build proteins out of amino acids, and from that baseline, we get life.We also get non-living things like viruses, which have no cells, metabolism, or independent reproduction, and phages are viruses.And while other AI models have been shown...
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    14 minutos
  • Ceuta Migrant Wave

    Ceuta Migrant Wave
    Aug 4 2026
    This week we talk about Melilla, hybrid warfare, and migration.We also discuss Morocco, civil conflict, and immigration politics.Recommended Book: Playground by Richard PowersTranscriptCeuta is a Spanish-owned territory located in northwestern Africa, along the top of Morocco. It’s small—about seven square miles—and is unusual because it is a city owned by a European Union member state that isn’t located on the European continent; it’s bordered by Morocco and the Mediterranean, and is located at the entrance of the Strait of Gibraltar, which is the strait that separates the Mediterranean Sea from the Atlantic Ocean.Ceuta is one of two territories that Spain still holds in Africa, the other being a smaller, just 4.7 square mile city called Melilla, which is located further west but still along the Mediterranean coast, bordered by the sea on one side, and by Morocco on the other.Spain has held both of these territories for hundreds of years: Ceuta since 1580 and Melilla since 1497, so it’s actually held them far longer than Morocco has been an independent state, in 1956. The populations of these territories, just over 85,000 people in each, also heavily identify as Spanish, despite many residents having Moroccan ancestry, so theres a cultural component here, too.That said, Morocco officially claims both areas as their own, considering them to be occupied territories, a bit like the Crimean peninsula has been militarily held by Russia since 2014, but it’s still claimed by Ukraine as an occupied territory. So the Moroccan government isn’t thrilled about having these small chunks of land, autonomous cities that are technically part of Spain, right there in the midst of their own territory. But these cities have been part of Spain for so long, and the residents are all Spanish citizens, with the same rights and sense of culture as the rest of Spain and Europe, that simply handing them over to Morocco has never seemed terribly feasible or desirable to the Spanish government, despite neither territory providing much strategic or economic value to Spain. So they remain a point of contention between these two governments.They’ve also served as migration hot-spots in recent decades, because they are the only two European territories that border an African country. And this is important because, in some cases, under some governments and in accordance with some laws, if you can make it across a border and into another country, you might be able to enter the system and eventually become a citizen, maybe claiming asylum or maybe getting slotted into some other path to citizenship. Or failing that, there’s a chance you might be able to just fade into the background, working and living in that country, despite not legally being there.What I’d like to talk about today is a recent surge in migrants crossing the border from Morocco into Ceuta, and the larger state of play, migration-wise, globally right now.—On the last day of July, 2026, an estimated 50-60 thousand African migrants illegally crossed from Morocco into Ceuta, some of them swimming to bypass the 20-foot-high border fences, others climbing those fences, or piling into overflowing boats, arriving in Ceuta en masse and overwhelming the guards who tried to stop them, though generally just trying to run past them, not attacking the guards—this wasn’t an attack, it was a rush to get into Spanish territory.Eventually the guards were reinforced by police and the Spanish military, and they started to push the waves of migrants back using water cannons and tear gas. But despite the less-lethal crowd control methods that were applied, at least 67 people, that’s the number as of the day I’m recording this at least, it’s been updated many times over the past few days, 67 people died as a result of stampedes, either headed inland or back into the sea, away from the gas and water cannons, or they drowned while trying to cross over the water.By the following day, the wave of migrants had become just a trickle, mostly a few stragglers who tried to swim to Ceuta, and who were swiftly returned to Morocco by local law enforcement. Almost everyone else who illegally crossed the border also returned to Morocco moved on by police or of their own volition, and though, again, this wasn’t some kind of violent incursion, to get a sense of the scale of this wave of humanity, Ceuta only has about 85,000 people living there, and this wave of migrants was about 60,000 people strong. So the locals mostly closed up all their shops and locked their doors, the people who arrived found themselves unable to get food or water, and law enforcement told them they need to leave, so most did. As of the day I’m recording this there are still several hundred migrants hiding in the nearby hills and lounging on the beach, exhausted and still hopeful they’ll be able to enter the asylum system—many of them saying they fled conflicts further south, like the ...
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    16 minutos
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