Let's Know Things Podcast Por Colin Wright capa

Let's Know Things

Let's Know Things

De: Colin Wright
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A calm, non-shouty, non-polemical, weekly news analysis podcast for folks of all stripes and leanings who want to know more about what's happening in the world around them. Hosted by analytic journalist Colin Wright since 2016.

letsknowthings.substack.comColin Wright Política e Governo
Episódios
  • US-Canada Tariffs

    US-Canada Tariffs
    Aug 25 2026
    This week we talk about borders, trade wars, and belligerence.We also discuss Trump’s tariffs, inflation, and nationalism.Recommended Book: Vulture Capitalism by Grace BlakeleyTranscriptThe US and Canada share the longest international border in the world, totaling more than 5,500 miles, or nearly 8,900 km. The specific details of this border have changed over the decades, but the current delineation was largely in place following the San Juan Islands water arbitration of 1872, which brought a 12-year joint military standoff between the US and Great Britain, known as the Pig War, to an end, and fed into a 1908 legal framework that relied on modern mapping of the entire frontier, which led to the precise cartography of the current international border between the US and Canada.Since then, after some issues with gold rush-era land rights were figured out in Alaska, and some treaties were signed regarding the disarmament of the Great Lakes, things have been pretty calm along this massive border. Trade hasn’t always been the most efficient and free—the early 20th century in particular was pretty fraught in this regard, as Anti-Americanism raged through Canada. That led to a dismissal of a proposed lowering of trade barriers by the Canadian Liberal government in 1911, anti-American sentiment flogged by the Conservatives, who rode their slogan, “No truck or trade with the Yankees,” to a Canadian nationalism-powered victory.After the US entered WWI and the Allies tallied a victory, though, the US and Canada exchanged their first ambassadors, Warren Harding became the first US President to make an official visit the confederated Canada, visiting Vancouver in 1923, and things between these two countries were looking pretty good until 1930, when the US passed the Smoot-Hawley Tariff Act, which was a protectionist trade act that, among other things, raised tariffs on incoming Canadian goods in order to protect competing American business interests; making the local offerings artificially more competitive than the stuff coming in from Canada, basically.The Canadian government hit back with their own higher tariffs and shifted more of their trade to other Commonwealth nations, which led to a decrease in trade between the US and Canada of about 75%; and this was happening during the Great Depression, which is why that Act was enacted, the US government was hoping to bolster their own economy, but instead of helping, it furthered those economic difficulties, because of that drop in trade and international custom—Smoot-Hawley is generally considered to have been an incredibly bad economic move, and US President Hoover signed it against the advice of senior economists, because it seemed politically expedient, US businesses were clamoring for advantages because they thought it would help them, but instead it worsened the Great Depression, and this Act is now taught as a cautionary example of why protectionist trade policies, while appealing in a nationalist sense, tend to be pretty bad, almost always, economically.US-Canadian relations improved a bit in the WWII-era, and into the early decades of the Cold War. By the late-1960s, the US had become Canada’s largest export market, and that’s why Nixon’s 1971 decision to enact a 10% tariff on all imports, including those from Canada, hit the Canadian economy so hard. Overall US-Canadian relations soured during Nixon’s time in the White House, in part because the Canadian government pivoted toward Europe, rather than kowtowing to the US’ economic demands, and Nixon’s belligerence in the face of that pivot didn’t help matters.When US President Carter stepped into office, however, things improved for a while, and though there were serious bouts of stagflation in both nations through his time in the White House, American investment in Canada increased, and relations continued to be friendly leading into the 1990s, at which point the North American Free Trade Agreement, or NAFTA was signed, in 1994. NAFTA created a common market in North America, between the US, Canada, and Mexico, and that meant the $19 trillion or so in trade between the 470 million people or so living in North America by 2014, would be entirely or almost entirely without barriers, no tariffs or very small, focused tariffs.Though imperfect by many measures, NAFTA is generally considered to have been a major success, at least in terms of raw economic productivity in North America. And in 2020, is was replaced by the USMCA, the United States-Mexico-Canada Agreement, which is often called NAFTA 2.0, which is in many ways just a modernization of NAFTA that updates many of the earlier provisions and focuses more on digital trade and intellectual property than its precursor.In July of 2026, however, the US government announced that it would not be renewing the USMCA, after Canada asked the US and Mexico to renew it for another 16 years. The pact remains in effect until it expires in 2036, ...
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    16 minutos
  • English Hepatitis C Progress

    English Hepatitis C Progress
    Aug 18 2026
    This week we talk about the liver, viral infections, and the NHS.We also discuss blood scandals, needle usage, and Nobel Prizes.Recommended Book: A World Appears by Michael PollanTranscriptThe term “hepatitis” refers to the inflammation of the liver, which can result from all kinds of things, including environmental toxins, the consumption of alcohol, or autoimmune diseases. It can also result from viral infections, and the most prominent liver-inflaming viruses are called viral hepatitis.There are five types of viral hepatitis, A, B, C, D, and E, and each of these viruses are distinct, not part of the same viral family, they’re just similarly named because they impact the same organ.Hepatitis A and E are primarily spread through contaminated food and water, and generally resolve on their own, untreated, and cause relatively mild symptoms. Hepatitis B and C are spread through blood and other bodily fluids, and can linger in a host’s body for decades before even showing symptoms. Hepatitis D is a parasite of Hepatitis B, and thus only infects people who carry Hepatitis B.Now again, these are all different conditions that just happen to inflame the liver, so impact and treatment also vary quite a lot. As I mentioned, A and E generally present with mild symptoms and tend to go away on their own, while B and C can stick around a long time. There’s a vaccine for B, but no cure; you can treat it, but that treatment involves suppressing it, and keeping it suppressed, forever. Hep C, in contrast, is curable, and has been since 2014 using what are called direct-acting antiviral pills, but these pills, which are taken for 8 to 12 weeks, are expensive—ranging from $22-95k without insurance, though that price is often reduced substantially for those with insurance, down to as low as $5. This category of drug coverage is often rejected by insurance companies, though, in part because they’re so expensive, that expense the result of little competition in this space; few companies make this type of drug, so those that do can charge more or less whatever they like.Some people with Hepatitis C clear it on their own; about 30% of people who contract it, in fact, clear it within a few months, medication-free. Which is good, because our understanding of this virus is relatively new. Up until 1989, Hep C didn’t even have its own name: it was established as its own thing, not Hep A and not Hep B, back in the 1970s, and doctors knew that something that wasn’t those two viruses, that was being spread by transfusions, was causing hepatitis symptoms, but they didn’t know any real specifics, so they just called it “non-A, non-B hepatitis,” and that name stuck for more than a decade.In 1989 the virus was cloned using molecular techniques (as opposed to simply growing the virus, which wasn’t proving fruitful in trying to isolate and identify the thing), and the folks who managed that cloning, and the person who later proved that the genome they cloned, alone, caused the disease, received a Nobel Prize in Medicine for their efforts in 2020.By 1991, antibody tests were available for Hep C, and many countries began screening donated blood for this virus, to ensure it wasn’t working its way into their blood supply.And one instance of that screening process, or I suppose, an event that led up to mass screening, and the consequences that followed, are what I’d like to talk about today. The UK’s efforts in trying to eliminate Hep C, and England’s recently announced near-success in that pursuit.—Hepatitis C is an RNA virus with high genetic variability that makes developing a reliable vaccine difficult. And though somewhere between a quarter and a third of all cases clear on their own, those that don’t clear on their own become chronic, lying in wait for twenty to thirty years, slowly accumulating fibrosis—thick scar tissue in the liver—which eventually results in cirrhosis, which means a liver that’s so heavily scarred that the organ is no longer fully functional and the damage is permanent. From there, infected people often experience liver failure or hepatocellular (huh-pah-toe) carcinoma, liver cancer.So this virus is a sleeper, and unless it’s caught by accident somewhere along the way, it slowly causes damage over time until the damage is too severe to reverse. About 80% of people who have it don’t know they have it, and in some parts of the world medical injections are the most common transmitter, but in higher-income areas, it’s usually transmitted by injectable drugs.Pre-2014 treatments for Hep C were pretty horrible, involving a combination antiviral therapy called pegylated interferon plus ribavirin that was injected weekly for six months to a year, and this was terribly tolerated by pretty much everyone, causing anemia, depression, and flu-like symptoms for the duration. It also only cured about 50% of people who received the full treatment, and a lot of people had to stop ...
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    16 minutos
  • AI-Designed Viruses

    AI-Designed Viruses
    Aug 11 2026
    This week we talk about Evo 2, bacteriophages, and antibiotics.We also discuss AI models, medical innovations, and the Red Army.Recommended Book: The Design of Everyday Things by Donald A. NormanTranscriptA bacteriophage, sometimes just called a phage, is a type of virus that only infects bacteria. “Phage” means to devour, and that’s what bacteriophages do—they infect and replicate within bacteria that they target, injecting their own genome into that target’s cytoplasm, which are all the materials contained within the bacteria’s cell membrane.Phages are super-abundant, by some measures more abundant than every living organism, including bacteria, on earth, combined. And they’re interesting in that they range from incredibly simple to quite complex, and have at times been used as alternatives to antibiotics, because they attack and feed on bacteria.The use of phages to counter bacterial infections was all but abandoned in the mid-20th century when antibiotics were discovered and commercialized, their production industrialized and the substances themselves proving a lot easier to mass-produce, and a lot more predictable in their utility than phages. Phages were kinda sorta almost understood, but we didn’t really get what they were doing or why, so their application often felt more like folk remedies than real-deal science, despite the actual science underlying the practice.Also, phages were primarily used as antibiotic treatments by the Red Army, the Soviet Union’s military. So throughout the West, which was rapidly scaling its production of antibiotic treatments, the use of bacteriophages was associated with Stalinist communism, and so the Red-scare, the demonization of anything associated with the Soviet Union, was partially responsible for the shelving of this approach and this realm of research, at least for a while.Much of that existing research was also done in the Soviet Union, and the published documents were thus published in Russian or Georgian languages. And because much of the rest of the scientific publishing world was reorienting around English at this time, that meant these published works were often either ignored or unintelligible to the rest of the scientific community.As with much of our microbiota, the invisibly small viruses, bacteria, archaea, and so on that make up the human microbiome, we have a general sense of how bacteriophages interact with some of what makes us, us, but only a general sense. We know that healthy individuals tend to contain a host of bacteriophages that people who have chronic conditions, like Crohn’s disease or ulcerative colitis are less likely to have, for instance, and there’s a chance that this lack is associated with those conditions—though each person’s body composition is unique, and this facet of biology is still relatively obscure; we really don’t know for certain what does what, because of how complex these interactions are.What I’d like to talk about today is a recent development in the world of bacteriophages, and why the researchers behind it are both celebrating their accomplishment, and warning about potential dangers associated with the same.—Back in 2025, a nonprofit called the Arc Institute, which has a stated goal of accelerating scientific progress and understanding the root causes of complex diseases, announced the release of a new language model, a new AI system, called Evo 2.The Evo family of foundation models—a foundation model being a type of AI model that’s been trained on a huge corpus of data, but which is applicable for all sorts of purposes, including serving as the foundation of large-language models like ChatGPT or Claude—this family of foundation models is open-source and trained on raw genetic sequences, something like nine trillion nucleotides-worth of such sequences, making it distinct from other models in this space that have been trained on descriptions of biological systems, using human language.The initial version of Evo was released in early 2024, and the newest version, Evo 2, which is an upgraded version of the Evo 2 model that is more efficient, so it can be run on less powerful hardware, was released in February of 2026.So while many of the AI systems that non-biologists interact with on a regular basis have been trained on human language-based libraries, showing relationships and interactions between the words we use to communicate, these models have been trained on the fundamental building blocks of life; the nucleotides, Adenine, Thymine, Cytosine, and Guanine, ATCG of DNA, if you remember that from biology class, that are strung together into 64 different possible three-letter combinations. Chains of these nucleotides instruct cells to build proteins out of amino acids, and from that baseline, we get life.We also get non-living things like viruses, which have no cells, metabolism, or independent reproduction, and phages are viruses.And while other AI models have been shown...
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    14 minutos
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