Dr. Anderson is currently the Albert H. Coons Professor of Neurology at Harvard Medical School, Senior Scientist at the Brigham and Women’s Hospital, Institute Member of the Broad Institute of MIT and Harvard, and Core Faculty Member of the Gene Lay Institute of Immunology and Inflammation. She talks about her research on immune regulation in cancer and enhancing anti-tumor immunity. (38:33)

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CAR Tregs for Atherosclerosis: Anti-oxidized low-density lipoprotein CAR Tregs reduce atherosclerotic plaque formation in mouse models. (2:20)

Tumor-Reactive T Cells: Tumor-reactive CD8+ T cells can be isolated and expanded from clinical samples. (14:24)

Harnessing Myeloid and Lymphoid Synergy for Immunotherapy: Myeloid-targeted immunocytokines and natural killer/T cell enhancers show potential for treating solid cancers. (18:50)

Subcutaneous Fat Affects Intestinal Aging: Subcutaneous white adipose tissue dysfunction triggers aging-like intestinal dysfunctions in mouse models. (32:40)

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Dr. George Robinson is a Principal Research Fellow at University College London, where his lab focuses on juvenile-onset systemic lupus erythematosus. He discusses current approaches to diagnosis and treatment, as well as the role of sex differences in autoimmunity. (31:20)

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Long-Term Allergies: Allergy-associated IgE plasma cells exhibit limited accrual in the bone marrow, and instead reside in other tissues for extended periods. (3:40)

Oral Immunotherapy for Peanut Allergy: Peanut oral immunotherapy reshapes T cell responses, suppressing allergy-associated type 2 helper T cells and boosting cytotoxic type 1 helper T cells, offering clues to long-term tolerance. (9:00)

Neuroprotective Microglia in Alzheimer’s Disease: The protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with amyloid plaques. (18:09)

Autoimmunity in ALS: Researchers showed that ALS is associated with recognition of the C9orf72 antigen and mapped the specific epitopes that are recognized. (23:20)

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Dr. Camila Coelho is a Principal Investigator at the Icahn School of Medicine at Mount Sinai, where her lab studies emerging pathogens. She talks about her lab’s work on mpox and other viruses, her approach to mentorship, and how her MBA education helps her in science. (36:00)

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Epigenetic Programming of T Cells – Researchers developed an all-RNA platform for efficient, durable and multiplexed epigenetic programming in primary human T cells. (3:57)

Converting Conventional T Cells to Tregs – Using a combination of cytokines and pharmacological approaches, conventional effector T cells can be converted into functional and stable Tregs. (9:40)

A Host–Pathogen Arms Race – E. coli uses the effector NleL to suppress epithelial extrusion, which aids in bacterial spread. (23:06)

Lactation and Lowered Breast Cancer Risk – Parity induces an accumulation of CD8+ T cells in breast tissue, which reduced tumor growth and increased immune cell infiltration in a mouse model. (28:13)

Image courtesy of Dr. Camila Coelho

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